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Celiac Disease: Mucosal Pattern in the Duodenum

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Duodenal mucosa in a patient with coeliac disease

Coeliac Disease (Gluten-sensitive enteropathy) A disease the typical feature of which is an intestinal mucosa damage secondary to the intake of gluten, a protein found in wheat, rye and barley. Symptoms may start in early childhood or in adult life. The clinical picture is of two types: intestinal symptoms or symptoms due to nutritional deficiencies (anaemia, osteoporosis). If untreated there is an elevated risk of intestinal malignancies. The prevalence of coeliac disease is probably about 1/100. A preliminary diagnose can be made by serology (Gliadin-, endomysium and reticulin-antibodies) but to get a firm diagnose a small bowel biopsy is needed. The treatment of this disease is a lifelong och strict glutenfree diet, and when properly treated, the prognosis is excellent.

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