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Collagenous Colitis

Collagenous Colitis

This disease was originally described by the Swedish doctor CG Lindström in 1976. It is a rare disease, mostly affecting women in the middle age, and causing watery diarrea up to 5 liters per day. The colon looks normal in colonoscopy, but in histological specimens an abnormal subepithelial collagen band is seen.

In this microscopic picture, the pink band beneath the mucosa surface is the collagen band typical for collagenous colitis.

Collagenous Colitis

The prognosis is good, and the patient may spontaneously recover after some years of diarrhea. Treatment with sulphasalazin or corticosteroids does sometimes help, but by no means always.

Findings in Colonscopy

In colonoscopy the bowel looks normal. In the picture to the right, a biopsy is taken, and the biopsy will give us the diagnosis.