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the GASTROLAB Digestive Dictionary

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NAFL Nonalcoholic fatty liver, nonalcohol-induced fatty liver.

NANB (Abbr) Non A Non B (used in connection with hepatitis)

NANBH (Abbr) Non A Non B Hepatitis (most often C-hepatitis, this term was used before C-hepatitis virus was identified)

NASH Nonalcoholic steatohepatitis

Natalizumab A drug currently being developed by Elan Pharmaceuticals, a monoclonal antibody, to be used in the treatment of Crohn´s disease and Multiple Sclerosis. Trade mark: Antegren.

National Colorectal Cancer Research Alliance Awareness (NCCRA) An nonprofit organization in the USA, the mission of which is to increase the awareness of colorectal cancer and preventive testing to exclude this disease.

Nausea A feeling of a need to vomit

NCCRA See National Colorectal Cancer Research Alliance Awareness

Acute necrotizing oesophagitis

Necrotizing oesophagitis, acute is a severe condition rarely seen in elderly most often seriously ill patients. The etiology of this disease is thought to be an ischemic injury and/or a serious infection. The main symptoms are painful swallowing and bleeding, hematemesis. This condition can occur in the postoperative period, in patients with metastatic cancer and it might be associated with some drug treatment. After healing oesophageal strictures are often seen. The oesophageal wall often darkens, hence the name "black oesophagus". Lye ingestion, acanthosis nigricans and primary pigmented melanoma are the main differential diagnoses.

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Recurrent Crohns disease in a neoterminal ileum

Neoterminal Ileum The "new" last part of the small bowel after a surgical resection of ileum terminale or after an ileocaecal resection. If the resection was done because of Crohns disease, a recurrent Crohns disease in the neoterminal ileum is common.

NERD (Abbr) Non-Erosive Reflux Disease. Could also mean Negative-Endoscopy Reflux Disease, a condition where the patient has reflux symptoms without any findings in endoscopy.

Neurotensin A gastrointestinal hormone produced in the last part of the small bowel. The main physiological effect is delaying of gastric emptying.

Nexium Registered trade mark for esomeprazole, a new "secon generation" proton pump inhibitor developed by AstraZeneca. Esomperazole has a greater and faster effect on gastric acid secretion than the older PPI´s.

NIAID National Institute of Allergy and Infectious Diseases (in USA)

Nissen fundoplication See fundoplication

NNH (Abbr) Number Needed to Harm, the number of patients receiving a treatment that would lead to on case of a harmful side effect of the treatment.

NNT (Abbr) Number Needed to Treat, the number of patients who need to be treated in order to prevent one atack of disease, for example the number of patients needed to be treated with ulcer medications in order to prevent one gastrointestinal bleeding.

NOD2-gene See Gene

Noct- (pre) Concering night, e.g. nocturia, the passage of urin at night

Non A-E viral hepatitis Viral hepatitis not caused by the known hepatitis viruses (A, B, C, D, E). Epstein-Barr virus and cytomegalovirus can cause acute hepatitis and there are probably still some unknown virus which can cause acute liver injury.

Nonorganic dyspepsia See Nonulcer dyspepsia

Nontropical sprue An old name of the disease now known as coeliac disease or gluten enteropathy

Nonulcer dyspepsia Pain in the upper abdomen resembling the symtoms of gastric ulcer disease, but without any significant findings in upper endoscopy. About two thirds of patients with upper abdominal pain do not have any abnormalities in routine examinations, and nonulcer dyspepsia is a very common disorder.. This dyspepsia has many names: nonorganic dyspepsia, essential dyspepsia and dyspepsia of unknown origin. Drugs used in the treatment of ulcer disease are quite often effective also in nonulcer dyspepsia.

Normo- (pre) Normal, for example normotensive, with normal (blood-) pressure

Normocyte A red blood cell with a normal size.

Nosocomial (Adj) Describing an infectious disease spreading in hospital environment. Also the hospital staff can get nosocomial infections.

NOTES (Abbr> Natural Orifice Transluminal Endoscopic Surgery

NSAID (Abbr) Nonsteroidal Antiinflammatory Drug

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May 3, 2007